Application of oxycodone hydrochloride injection on anesthesia and postoperative analgesia in patients undergoing radical resection of colorectal cancer / 医学研究生学报

Objective　The choice of perioperative analgesic drugs for radical resection of colorectal cancer is controversial. The purpose of this paper is to investigate the efficacy of oxycodone hydrochloride injection on anesthesia and postoperative analgesia in patients with radical resection of colorectal cancer, to provide a basis for the selection of such surgical analgesics.　Methods　Between July 2017 and December 2017, selection of 38 patients with colorectal cancer underwent elective open surgical operation in the Eastern Theater General Hospital, the age range was 18～65 years, the BMI range was 18～25 kg/m2, the ASA was Ⅱ or Ⅲ grade, who were divided to two groups according to randomized, single blind and controlled methods, the oxycodone group was group O, the sufentanil was group S, each group had 19 cases. Oxycodone 0.3 mg/kg (group O) and sufentanil 0.3 μg/kg (group S) were given at general anesthesia induction in both groups.The anesthesia maintenance medication was consistent in both groups. When sewing skin, the group O were given oxycodone 0.15 mg/kg, the group S were given sufentanil 0.15 μg/kg , and who were given PCIA postoperative, the group O were given oxycodone 1 mg/kg and Azhasi 10 mg, while the group S were given sufentanil 2.5 μg/kg and Azhasi 10 mg, which were diluted with normal saline to 100 mL. The NRS score postoperative and the Ramsay sedation scores were recorded when extubating（T1）, 4 hours after operation（T2）, 12 hours after operation（T3）, 24 hours after operation（T4） and 48 hours after operation（T5）in two groups ; the plasma cortisol, MAP(mean arterial pressure) and HR(heart rate) before and after intubation in two groups were recorded; the extubation time, first bowel ventilation time, PCIA compressions and adverse reactions in two groups were recorded.　Results　The age, weight, anesthesia duration had no significant difference in two groups (P> 0.05). Compared with group S, the NRS scores were obvious decreased in group O at all time points（P 0.05). Compared with before intubation, the MAP were both decreased at intubation and after intubation 5min in group O (P 0.05) .　Conclusion　Compared with sufentanil, oxycodone was safer and more effective on general anesthesia induction and postoperative analgesia in radical resection of colorectal cancer.

Influence of histological prostatitis on the clinical features of benign prostatic hyperplasia and prostate cancer / 中华男科学杂志

<p><b>OBJECTIVE</b>To investigate the influence of histological prostatitis (HP) on the clinical features of benign prostatic hyperplasia (BPH) and prostate cancer (PCa) and its clinical significance.</p><p><b>METHODS</b>We retrospectively studied the data of 273 cases of BPH and 240 cases of PCa, including age, prostate volume, total prostatic special antigen (tPSA), prostatic special antigen density (PSAD), maximum urinary flow rate (MFR) and acute urinary retention (AUR).</p><p><b>RESULTS</b>Totally, 186 cases of BPH (68.13%) and 45 cases of PCa (18.75%) were complicated by HP, with statistically significant difference between the two groups (P < 0.05). Compared with the patients with BPH only, those complicated by HP showed significantly elevated tPSA, PSAD and total prostate volume (all P < 0.05), decreased MFR (P < 0.05) and increased risk of AUR (P < 0.05). There was no significant difference in the patients' age between the two groups (P > 0.05). The levels of tPSA and PSAD were remarkably higher in the PCa patients complicated by HP than in those with PCa only (all P < 0.05), but no significant differences were found in the other indexes between the two groups (P > 0.05).</p><p><b>CONCLUSION</b>HP may play a certain role in the progenesis and progression of HP and PCa, but HP is associated more closely with BPH.</p>

Study on sustainable development of industy of ethnic medicine in minority area / 中国中药杂志

Ethnic medicine industry is facing many problems such as narrow market, exhaustion of resource, decline of ethnic medicine and no qualified successors. Sustainable development theory was utilized to analyse the elements and problems of ethnic medicine industry, and the counter measures were put forward to get rid of the predicament and to realize the sustainable development which depends on the ethnic medicine resources, national medicine, industrial policy, personnel training and modern technology. The development issues of ethnic medicine industry can be solved by the coordination of enterprise, government and public. Finally the ethnic medicine can provide better services for society.

Research of the relationship between cervical cytology and HPV test and lesions in the cervical tissue / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>Discussion of the relationship between cervical cytology and high-risk HPV test and lesions in the cervical tissue.</p><p><b>METHOD</b>The 254 infertile patients were graded into 4 groups based on the results of cervical cytology and high-risk HPV test. The patients in group A were the cervical cytology -positive and HPV-positive. The cervical cytology -positive and HPV-negative patients were in group B. The cervical cytology -negative and HPV-positive patients were in group C and cervical cytology -negative and HPV-negative in group D. Retrospective analysis was used in the relationship between the results and lesions in the cervical tissue.</p><p><b>RESULTS</b>The incidence of CIN II and higher grade than CIN II was significant higher in group A than in group B (P < 0.01). The incidence of CIN I was no difference among A, B and C group (P > 0.05). The sensitivity was 100.0% and the specificity was 46.74% when cervical cytology was used to test the CIN II grade. But the sensitivity changed to 97.22% and the specificity 87.16% when both of the cervical cytology and HPV test were used.</p><p><b>CONCLUSION</b>The cervical cytology is the first choice in cervical examination. And the accuracy will significant higher when the HPV test is used simultaneously.</p>

The treatment research of people with different types of HPV infection in sterile patients / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>Explore the optimal treatment of infertility patients infected with different types of human papillomavirus (HPV).</p><p><b>METHODS</b>According to cervical pathology, cervical status and the procreate desire of the infertility patients, the 144 clinic cases of high-risk human papillomavirus infected infertile patients were divided into two gruoups: group with treatment and without treatment. Real-time quantitative fluorescent PCR (RT-PCR) has been employed, follow-up time is 6 months, to detect the HPV-DNA in the crevical exfoliated cells, to observe the negative conversion rate and pregnancy rate, and compare analyzed.</p><p><b>RESULTS</b>(1) In high-risk HPV infectors, the negative conversion rate of treatment group (56.67%) is higher than those in non-treatment group (50.00%); (2) The pregnancy rate of secondary high-risk HPV non-treatment group (50.00%) is higher than the treatment group. The pregnancy rate of primary high-risk HPV treatment group (31.67%) is higher than the non-treatment group (4.00%). (3) Negative conversion rate increases accordingly, on primary high-risk HPV infected groups with Leep, with single drug and with Leep combined with drug therapy. (4) The negative conversion rate and the pregnancy rate of primary high-risk HPV infected groups with surgical therapy is higher than the groups with drug therapy. Surgical + Drugs is better in the two surgical therapies.</p><p><b>CONCLUSION</b>Infertile patients should be routinely screened for cervical HPV. The primary high-risk cervical HPV infection is the etiology of infertility. Preferably, patients with primary high-risk HPV infection in cervical lesions is treated with Leep combined drugs.</p>

Relationship between mycoplasma and chlamydia infection and lesions in the cervical tissue in high-risk HPV-positive patients / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>Discussion of the relationship between Mycoplasma and chlamydia infection and lesions in the cervical tissue in high-risk HPV-positive infertile patients with cervical.</p><p><b>METHODS</b>HPV-negative patients with cervical as the control, retrospective analysis the relationship of Mycoplasma hominis and chlamydia infection, cervical histological graded, and inflammation graded.</p><p><b>RESULTS</b>The rate of HPV infection in mycoplasma-positive and those with negative mycoplasma has significant difference (P < 0.01), The rate of HPV infection in chlamydia-positive and those with negative chlamydia has no significant difference (P > 0.05). CIN and the incidence of cervical erosion and CIN grade were higher in HPV-positive than HPV-negative group (P < 0.01). The cervical erosion of HPV-positive was no difference in the degree (P > 0.05). Compared with the simple HPV-positive group, CIN and the incidence of severe cervical erosion in mixed infection of Mycoplasma was no difference (P > 0.05).</p><p><b>CONCLUSION</b>Mycoplasma infection increases the rate of high risk HPV infection, high-risk HPV infection increased cervical pathological damage, Mycoplasma infection might be the factor of persistent infection with high risk HPV, the degree of cervical pathological is the factor of cervical infertility which can not be ignored.</p>

Investigation on HPV viral load and high risk HPV types infection among patients with infertility / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>High risk human papilomavirus (HPV) infection is often related to cervical cancer. This study investigated the infection of high risk HPV in cervical epithelia among infertile patients. Relative quantification and absolute quantification were applied for determination of "real" HPV viral load in the clinical setting.</p><p><b>METHODS</b>Adopting multi-channels real time PCR to genotype and quantify eight high risk HPV (HPV16, 18, 45, 31; intermediate risk types: HPV33, 52, 58, 67) DNA in cervical epithelia of the 130 infertile patients and the 150 controls. This study applied housekeeping gene (beta-globin) for the DNA quantification on secretions samples for clinical diagnosis.</p><p><b>RESULTS</b>The infection rate of the infertility group was 25.38 percent (33/130) and that of the control group was 11.33 percent (17/150), the difference was statistically significant. Among the 33 positive cases in the infertility group, 24 cases showed a viral load no less than 106; in 9 of them, the viral load was less than 106. Among the 17 positive cases in the control group, 4 cases had a viral load no less than 106; in 13 of them, the viral load was less than 106. There is a statistically significant difference in viral load between the infertility group and the control group.</p><p><b>CONCLUSION</b>The HPV infection rate of the infertility group was higher than that of the control group.</p>

Medical waveform format encoding rules (MFER)--analysis and implementation / 中国医疗器械杂志

There is not yet a universally acknowledged standard for all kinds of general medical waveform format encoding. Medical Waveform Format Encoding Rules (MFER) presented by Japanese IS&C Committee can parse and describe all kinds of routine medical waveform data. In this paper, MFER's working out, its present situation and characters are expatiated and MFER rules are interpreted in detail. MFER, medical waveform, standard